Oral Treatment of Diabetes with Tolbutamide
نویسندگان
چکیده
منابع مشابه
Serum tolbutamide and chlorpropamide concentrations in patients with diabetes mellitus.
A selective and sensitive gas chromatographic technique was used to measure the steady-state serum concentrations of tolbutamide and chlorpropamide in 97 patients with maturity-onset diabetes mellitus who had been taking these drugs (37 tolbutamide, 60 chlorpropamide) for at least a year. No other antidiabetic agents had been given. The serum tolbutamide concentrations varied widely between the...
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چکیده ندارد.
15 صفحه اولOral bioavailability and hypoglycaemic activity of tolbutamide/cyclodextrin inclusion complexes.
The purpose of the present study was to evaluate the enhancement of tolbutamide (TBM) oral bioavailability and hypoglycaemic activity through complexation with beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD). TBM and its freeze-dried inclusion complexes were administered to rabbits (New zealand breed; n=6), in a dose of 20 mg/kg. TMB plasma levels were measured by H...
متن کاملResponse of a diabetic strain of mouse to oral tolbutamide.
Search is constantly going on to find an animal with diabetes mellitus like features so that a model akin to human diabetes is available for screening of potential hypoglycemic agents of both plant and synthetic origin. The KK strain of mice was discovered by Nakamura (1). Nakamura (1) has shown by carrying out glucose tolerance tests on 28 KK strain of mice that the majority show a blood sugar...
متن کاملThe effects of tolbutamide on the myocardium in experimental diabetes.
The effects of chronic tolbutamide treatment were examined in a diabetic animal model in which abnormal myocardial function and composition have previously been demonstrated. Eight diabetic dogs were given tolbutamide 250 mg/day orally and compared with seven untreated diabetics, five healthy dogs receiving tolbutamide, and eight normal controls. After one year, resting hemodynamic studies in t...
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ژورنال
عنوان ژورنال: BMJ
سال: 1957
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5057.1345